Lowering alpha-synuclein as a Therapeutic Strategy for Parkinson's disease: Challenges & Possibilities
α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology - ScienceDirect
Internalization, axonal transport and release of fibrillar forms of alpha-synuclein - ScienceDirect
Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment | Acta Neuropathologica Communications | Full Text
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Figure 2 from Preventing α-synuclein aggregation: the role of the small heat-shock molecular chaperone proteins. | Semantic Scholar
Akamai Blog | Anatomy of a SYN-ACK Attack
Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies: Cell
IJMS | Free Full-Text | Alpha-Synuclein as a Prominent Actor in the Inflammatory Synaptopathy of Parkinson's Disease
What is a SYN flood attack and how to prevent it? | NETSCOUT
IJMS | Free Full-Text | The Prion-Like Spreading of Alpha-Synuclein in Parkinson's Disease: Update on Models and Hypotheses
Cells | Free Full-Text | Alpha-Synuclein Aggregation Pathway in Parkinson’s Disease: Current Status and Novel Therapeutic Approaches
Proposed pathogenic mechanisms of α-syn-related Lewy body formation in... | Download Scientific Diagram
Heparin induces α-synuclein to form new fibril polymorphs with attenuated neuropathology | Nature Communications
Cells | Free Full-Text | Alpha-Synuclein Aggregation Pathway in Parkinson’s Disease: Current Status and Novel Therapeutic Approaches
Distinct alpha‐Synuclein species induced by seeding are selectively cleared by the Lysosome or the Proteasome in neuronally differentiated SH‐SY5Y cells - Pantazopoulou - 2021 - Journal of Neurochemistry - Wiley Online Library
Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease | Science
Inhibition of synucleinopathic seeding by rationally designed inhibitors | eLife
A Combined α-Synuclein/Fibril (SynFib) Model of Parkinson-Like Synucleinopathy Targeting the Nigrostriatal Dopamine System - IOS Press
Frontiers | Targeting Alpha-Synuclein as a Therapy for Parkinson's Disease
Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys - eBioMedicine